Navigation
What is dbSP
The dbSP is an integrative database of sensor proteins (SPs), which collected 399 literature and 2 datasets for 109 eukaryotic and prokaryotic sensing research. In total, 754 sensing events involving 7 sensing types on 712 SPs were collected and integrated in the database. By orthologous search, 477 orthologous proteins from 43 eukaryotes were obtained, with a total of 537 potential sensing events.
In living things, sensor proteins (SPs) undergo changes in activity or function under the direct affecting by signals, and then serve as key nodes of signaling cascades which are input terminals for environmental information.
How to use dbSP
Quick Search
In the home page of dbSP, users can specify one field or all the fields to perform a quick search with the keyword(s) in the field(s). Users can simply click example above the search bar to perform an example search.
Browse
In the Browse page, users can click one term to search the specified data in dbSP. The data was firstly grouped by organisms and further grouped by sensing types. Users can click the initial and select the term of interest.
advanced Search
In the Search page, users can add more keyword boxes and choose 'AND', 'OR' or 'NOT' to perform a more accurate multiple keywords search. Search results were shown below the search box, and users can click ‘More’ button to result page.
Result
The result page shows the results that users are interested and users can get more detailed results by click the 'Detail' button.
Sensor protein resources
BitterDB
The aim of BitterDB database is to gather information about bitter-tasting natural and synthetic compounds, and their cognate bitter taste receptors (T2Rs or TAS2Rs).
https://bitterdb.agri.huji.ac.il/dbbitter.phpORDB
ORDB began as a database of vertebrate OR genes and proteins and continues to support sequencing and analysis of these receptors by providing a comprehensive archive with search tools for this expanding family. Because of the associated growth of interest in other CRs, the database has grown over the years to include a broad range of chemosensory genes and proteins, that includes in addition to ORs the taste papilla receptors (TPRs), vomeronasal organ receptors (VNRs), insect olfactory receptors (IORs), Caenorhabditis elegans chemosensory receptors (CeCRs), fungal pheromone receptors (FPRs) [these are informal abbreviations for tracking in ORDB, pending development of consensus nomenclature by the field].
https://senselab.med.yale.edu/ORDB/VKCDB
VKCDB is a comprehensive sequence database of voltage-gated potassium channels (VKCs) from Eukaryotes, Bacteria and Archaea, designed to serve as a resource for research on VKC evolution and structure/function relationships. Protein sequences, corresponding nucleic acid sequences of open reading frames, references, information on the organisms of origin of each channel and functional data are stored in this database.
http://vkcdb.biology.ualberta.ca/