In all organisms, sensor proteins undergo conformational transition induced by the direct affecting of signals, and then serve as input-terminals for environmental information in sensing cascades. According to the type of environmental information sensed by sensor proteins, sensor proteins could be divided into physical signal sensor proteins, including photosensing proteins, mechanical force sensing proteins, temperature sensing proteins, voltage sensing proteins, magnetosensing proteins; and chemical signal sensor proteins, including olfactory receptors, taste receptors.
    Current progresses have proposed that sensor proteins play indispensable roles in extensive biological processes. Additionally, abundant studies have shown that dysfunction of sensor proteins will lead to certain human diseases Here, we developed an integrative database for sensor proteins in eukaryotes and prokaryotes named dbSP (database for sensor proteins) which curated and hosted 712 experimentally identified sensor proteins from 70 eukaryotes and 39 prokaryotes for 7 sensing types. 477 potential orthologs of known proteins in other 43 eukaryotes were computationally identified.